The performance of lipid profiles and ratios as a predictor of arterial stiffness measured by brachial-ankle pulse wave velocity in type 2 diabetic patients

Background: Early identification of arterial stiffness in Type 2 diabetes mellitus (T2DM) patients before the manifestation atherosclerosis would be clinically beneficial. Our study aimed to explore correlation lipid profiles and ratios with stiffness, construct a predictive model for T2DM using those parameters. Methods: One hundred eighty-four adult outpatient clinic at Dr. Soetomo general academic hospital were enrolled this cross-sectional 2015 2019. Sociodemographic, glycosylated hemoglobin (HbA1c), profiles, brachial-ankle pulse wave velocity (ba-PWV) data collected from all subjects. The subjects divided into group (ba-PWV > 18 m/sec) without ≤ m/sec). A test was used evaluate association, receiver operator characteristics (ROC) curves analysis determine cut-off value, sensitivity, specificity. risk calculated bivariate logistic regression analysis. Results: The had higher profiles: total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density (LDL-C), ratios. significant positive found between TC, TG, LDL-C, ba-PWV. negative HDL-C All ratio parameters can as predictors especially non-HDL-C value: 150 mg/dL (sensitivity 96.8% specificity 52.9%) TG/HDL-C 4.51 81.0% 74.2%). Elevated displayed (OR: 12.293 16.312; p < 0.05) having compared other ratios. Conclusions: Lipid ratios, non-HDL-C, are potential biochemical markers patients.